What is Zytiga 250 mg?
Zytiga 250 mg (Abiraterone Acetate) is a targeted oral therapy used in the treatment of advanced prostate cancer (metastatic castration-resistant prostate cancer – mCRPC). Manufactured by Janssen Pharmaceuticals, Zytiga works by blocking androgen production, slowing the growth of prostate tumors and extending patient survival rates.
Zytiga is often prescribed alongside prednisone, a corticosteroid that helps minimize the side effects of hormone suppression. It is a leading choice among oncologists for patients who have progressed on androgen deprivation therapy (ADT) or after chemotherapy with docetaxel.
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How Does Zytiga Work?
Zytiga contains Abiraterone Acetate, a CYP17 inhibitor that blocks the production of androgens (male hormones), which fuel the growth of prostate cancer cells. Unlike traditional hormone therapies, which only suppress testosterone production in the testes, Zytiga inhibits androgen synthesis in the adrenal glands, testes, and even within the tumor itself, offering a more comprehensive hormonal blockade.
By lowering androgen levels, Zytiga significantly slows tumor progression, reduces symptoms, and improves quality of life in patients with metastatic prostate cancer.
Who Should Use Zytiga?
Zytiga 250 mg is prescribed for:
✔️ Metastatic Castration-Resistant Prostate Cancer (mCRPC) – For patients who have not responded to traditional hormone therapy or have progressed despite treatment.
✔️ High-Risk Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) – In combination with androgen deprivation therapy (ADT).
✔️ Post-Chemotherapy Treatment – For patients who have previously received docetaxel chemotherapy and need further disease control.
Dosage & Administration: How to Take Zytiga?
- Formulation: Oral tablets (250 mg)
- Administration: Take on an empty stomach (at least 1 hour before or 2 hours after meals)
- Recommended Dosage:
- Standard dose: 1000 mg per day (4 tablets of 250 mg) taken once daily
- Prednisone co-administration: 5 mg twice daily
- Duration of Treatment: Continue as long as disease control is maintained and side effects are manageable
- Missed Dose: If a dose is missed, do not double up; simply take the next scheduled dose as usual.
Why Choose Zytiga Over Other Prostate Cancer Treatments?
✔️ Superior androgen blockade compared to standard hormone therapies.
✔️ Oral treatment – No need for injections, making it more convenient.
✔️ Significantly extends survival in patients with advanced prostate cancer.
✔️ Reduces tumor size and improves symptoms such as bone pain and urinary obstruction.
✔️ Widely prescribed by oncologists worldwide for mCRPC patients.
Side Effects of Zytiga
While Zytiga is well-tolerated, some patients may experience:
- Common Side Effects: Fatigue, high blood pressure, joint pain, swelling, low potassium levels.
- Serious Side Effects: Liver toxicity, increased risk of adrenal insufficiency, irregular heartbeat.
- Managing Side Effects: Regular blood tests are recommended to monitor liver function and potassium levels.
Precautions & Warnings
⚠️ Do not take Zytiga with food, as it may increase drug absorption and lead to side effects.
⚠️ Patients with severe liver disease should use caution and consult a doctor.
⚠️ Women (especially pregnant women) should not handle crushed or broken Zytiga tablets, as it can cause birth defects.
⚠️ Monitor blood pressure regularly, as hypertension is a potential side effect.
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