What is Xeljanz 5 mg?
Xeljanz (Tofacitinib Citrate) 5 mg is an oral Janus kinase (JAK) inhibitor used for the treatment of autoimmune diseases, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), ulcerative colitis (UC), and ankylosing spondylitis (AS). Developed by Pfizer, this targeted therapy helps reduce inflammation by modulating immune system activity.
Unlike traditional biologic treatments, Xeljanz does not require injections and is taken as a daily oral tablet, making it a convenient option for patients suffering from chronic inflammatory conditions.
How Does Xeljanz Work?
Xeljanz contains Tofacitinib, which works by selectively inhibiting Janus kinase (JAK) enzymes. These enzymes are responsible for signaling pathways involved in immune system activation and inflammatory responses. By blocking JAK activity, Xeljanz helps to:
✔️ Reduce inflammation in joints and the gastrointestinal tract.
✔️ Slow disease progression in rheumatoid arthritis and psoriatic arthritis.
✔️ Improve symptoms of ulcerative colitis by modulating immune activity.
✔️ Enhance mobility and reduce pain in autoimmune-related conditions.
Indications: What Conditions Does Xeljanz Treat?
Xeljanz 5 mg is approved for the treatment of:
✔️ Rheumatoid Arthritis (RA): In combination with methotrexate for patients with moderate to severe active RA.
✔️ Psoriatic Arthritis (PsA): For adults with active PsA who did not respond to TNF inhibitors.
✔️ Ulcerative Colitis (UC): Used for patients with moderate to severe UC who failed conventional therapies.
✔️ Ankylosing Spondylitis (AS): For reducing spinal inflammation and improving mobility.
Dosage & Administration: How to Use Xeljanz?
- Formulation: Film-coated tablet (oral use)
- Administration: Take with or without food
- Recommended Dosage:
- Rheumatoid & Psoriatic Arthritis: 5 mg twice daily or Xeljanz XR (once daily 11 mg)
- Ulcerative Colitis (UC): 10 mg twice daily for 8 weeks, followed by 5 mg twice daily for maintenance
- Ankylosing Spondylitis: 5 mg twice daily
- Missed Dose: If a dose is missed, take it as soon as possible unless it is close to the next scheduled dose.
Side Effects of Xeljanz
Although generally well-tolerated, some patients may experience:
- Common Side Effects: Headache, upper respiratory tract infections, nausea, diarrhea, and high blood pressure.
- Serious Side Effects: Increased risk of infections, blood clots, liver dysfunction, and gastrointestinal perforations (rare).
- Long-Term Risks: Patients should be monitored for heart disease, malignancies, and serious infections.
Why Choose Xeljanz Over Other Autoimmune Therapies?
✔️ Convenient oral tablet (no injections required).
✔️ Fast-acting relief for autoimmune inflammation.
✔️ Effective for TNF-inhibitor-resistant patients.
✔️ Approved for multiple autoimmune conditions.
Precautions & Warnings
⚠️ Patients with a history of blood clots or heart disease should use caution.
⚠️ Live vaccines should be avoided during treatment.
⚠️ Regular blood tests are required to monitor liver function and infection risk.
⚠️ May increase the risk of serious infections (e.g., tuberculosis, pneumonia).
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