What is Genvoya?
Genvoya is a combination antiviral medication used for the treatment of HIV-1 infection. Manufactured by Gilead Sciences, this once-daily pill contains four active ingredients: Elvitegravir (150 mg), Cobicistat (150 mg), Emtricitabine (200 mg), and Tenofovir alafenamide (10 mg). It is primarily prescribed for adults and adolescents who require antiretroviral therapy (ART) to manage HIV infection effectively.
Genvoya is an updated formulation of Stribild, designed to provide a more efficient and safer treatment with fewer kidney and bone-related side effects. It helps in suppressing the virus, reducing the risk of HIV progression, and improving the quality of life for individuals living with HIV.
How Does Genvoya Work?
Genvoya works by targeting different stages of the HIV replication process:
- Elvitegravir (INSTI – Integrase Strand Transfer Inhibitor): Blocks HIV from integrating into the host’s DNA.
- Cobicistat (Booster): Enhances the effectiveness of Elvitegravir by inhibiting liver enzymes that break down the drug too quickly.
- Emtricitabine (NRTI – Nucleoside Reverse Transcriptase Inhibitor): Prevents the virus from replicating by incorporating itself into the viral DNA.
- Tenofovir alafenamide (NRTI): A newer version of Tenofovir that reduces the risk of kidney and bone toxicity while effectively blocking HIV replication.
By combining these four active components, Genvoya achieves better viral suppression with a lower risk of drug resistance.
Indications: Who Should Use Genvoya?
Genvoya is prescribed for:
✔️ Adults and adolescents (aged 12 and above) diagnosed with HIV-1.
✔️ Patients without previous antiretroviral treatment or those with stable viral suppression.
✔️ Individuals looking for a safer alternative to older HIV medications with improved kidney and bone safety profiles.
Dosage & Administration: How to Take Genvoya?
- Formulation: Film-coated tablet
- Administration: Oral use (swallowed whole, preferably with food)
- Recommended Dosage: One tablet per day
- Food Requirement: Take with food for optimal absorption
- Missed Dose: If a dose is missed within 12 hours, take it as soon as possible. If more than 12 hours have passed, skip the missed dose and continue with the next scheduled dose.
Side Effects of Genvoya
Genvoya is generally well-tolerated, but some users may experience:
- Common Side Effects: Nausea, diarrhea, fatigue, headache, dizziness, and abdominal pain.
- Serious Side Effects: Liver problems, kidney dysfunction, and lactic acidosis (rare but serious).
- Bone Density Reduction: While lower than older Tenofovir-based regimens, a slight decrease in bone mineral density may still occur.
Why Choose Genvoya Over Other HIV Treatments?
✔️ Lower kidney and bone toxicity than older Tenofovir-based treatments.
✔️ Single-tablet regimen for convenience and adherence.
✔️ High barrier to resistance, making it suitable for long-term use.
✔️ Strong efficacy in viral suppression for both treatment-naïve and experienced patients.
Precautions & Warnings
⚠️ Do not use Genvoya with other antiretroviral drugs unless prescribed by a doctor.
⚠️ Not recommended for patients with severe kidney or liver disease.
⚠️ Patients with hepatitis B should consult their doctor before use.
⚠️ Avoid excessive alcohol consumption, as it may increase liver toxicity.
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