Copellor 80 mg/1 ml Solution for Injection Pre-Filled Pen is an innovative biologic medication designed to treat moderate to severe plaque psoriasis, psoriatic arthritis, and axial spondyloarthritis (including ankylosing spondylitis). Manufactured by Lilly, Copellor contains the active ingredient Ixekizumab, a monoclonal antibody that targets interleukin-17A (IL-17A), a key cytokine involved in the inflammatory process associated with autoimmune diseases.
This advanced treatment is highly regarded for its rapid symptom relief and long-term disease control, making it a preferred choice among patients and healthcare professionals seeking effective solutions for chronic inflammatory conditions.
Key Features and Benefits:
- Active Ingredient: Ixekizumab 80 mg
- Form: Pre-filled Pen (Ready-to-Use Autoinjector)
- Administration: Subcutaneous (Under-the-Skin) Injection
- Fast Symptom Relief: Demonstrated improvement in psoriasis symptoms as early as 1 week.
- High Efficacy: Achieves clear or almost clear skin in a majority of patients by week 12.
- Long-Term Disease Control: Effective for sustained management of plaque psoriasis, psoriatic arthritis, and axial spondyloarthritis.
- Patient-Friendly Design: Pre-filled autoinjector for easy, convenient, and accurate self-administration.
- Targeted IL-17A Inhibition: Reduces inflammation at the source, minimizing disease flares and improving quality of life.
Therapeutic Indications:
- Moderate to Severe Plaque Psoriasis in adults who are candidates for systemic therapy or phototherapy.
- Psoriatic Arthritis either alone or in combination with methotrexate.
- Axial Spondyloarthritis (AxSpA), including:
- Ankylosing Spondylitis (Radiographic AxSpA)
- Non-Radiographic AxSpA with objective signs of inflammation.
Mechanism of Action:
Copellor (Ixekizumab) is a monoclonal antibody specifically designed to block interleukin-17A (IL-17A), a cytokine that plays a pivotal role in the development and progression of psoriasis and related inflammatory diseases. By neutralizing IL-17A, Copellor reduces skin cell overproduction, alleviates joint inflammation, and prevents further tissue damage.
Dosage and Administration:
- Plaque Psoriasis: Initial dose 160 mg (two 80 mg injections) at week 0, followed by 80 mg every 2 weeks until week 12, then 80 mg every 4 weeks.
- Psoriatic Arthritis: 80 mg every 4 weeks after an initial 160 mg dose.
- Axial Spondyloarthritis: 80 mg every 4 weeks after an initial 160 mg dose.
Administer subcutaneously into the thigh, abdomen, or upper arm. Rotate injection sites to avoid irritation.
Safety Information:
- Contraindications: Patients with a known hypersensitivity to Ixekizumab or any excipients.
- Precautions: Increased risk of infections, including upper respiratory tract infections. Monitor patients for signs of infections during treatment.
- Adverse Reactions: Common side effects include:
- Injection site reactions (redness, pain, swelling)
- Upper respiratory tract infections
- Nausea
- Fungal infections
- Headache
- Serious Infections: Rare but possible. Discontinue use if a severe infection occurs.
- Pregnancy and Lactation: Use only if clearly necessary; consult a healthcare provider.
Storage Conditions:
- Store in a refrigerator (2°C to 8°C).
- Keep the pre-filled pen in the original packaging to protect it from light.
- Do not freeze or shake.
Why Choose Copellor (Ixekizumab)?
- Fast-Acting: Clearer skin in as little as 1 week.
- Convenience: Easy-to-use pre-filled pen for self-injection.
- Proven Results: Trusted worldwide for its high success rates in psoriasis and arthritis treatment.
- Enhanced Quality of Life: Reduces pain, scaling, stiffness, and inflammation, improving daily functionality and emotional well-being.
Manufacturer Information:
- Brand: Copellor
- Active Substance: Ixekizumab
- Dosage: 80 mg/1 ml Solution for Injection
- Presentation: 1 Pre-filled Pen (Autoinjector)
- Manufacturer: Eli Lilly and Company
- Country of Origin: USA
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