Adempas 2.5 mg Film-Coated Tablets, containing the active ingredient Riociguat, is a breakthrough medication developed by Bayer Pharmaceuticals. It is primarily prescribed for the treatment of pulmonary hypertension, a severe condition characterized by increased blood pressure in the arteries of the lungs. This medication is specifically indicated for chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat is part of a novel class of drugs known as soluble guanylate cyclase (sGC) stimulators, which work by relaxing and widening the blood vessels to improve blood flow and reduce the strain on the heart.
Key Benefits and Features:
- Active Ingredient: Riociguat – 2.5 mg per film-coated tablet.
- Pack Size: Each box contains 42 film-coated tablets.
- Manufacturer: Bayer Pharmaceuticals – A globally trusted pharmaceutical company.
- Indications:
- Chronic Thromboembolic Pulmonary Hypertension (CTEPH): For patients who cannot undergo surgery or have persistent hypertension after surgery.
- Pulmonary Arterial Hypertension (PAH): To improve exercise capacity and delay disease progression.
- Mechanism of Action:
Riociguat stimulates soluble guanylate cyclase (sGC), an enzyme responsible for relaxing the smooth muscles in blood vessels. By increasing the levels of cyclic guanosine monophosphate (cGMP), it helps widen the blood vessels, reducing pulmonary artery pressure and improving heart efficiency. - Proven Efficacy: Clinical trials have demonstrated that Adempas improves exercise tolerance, reduces symptoms such as shortness of breath, and enhances quality of life in pulmonary hypertension patients.
- Oral Administration: Easy-to-use oral tablet formulation, taken three times daily with or without food.
How Does Adempas (Riociguat) Work?
Adempas targets the nitric oxide (NO)-sGC-cGMP pathway, which is crucial for vascular relaxation and blood pressure regulation. In pulmonary hypertension, this pathway is often impaired. Riociguat sensitizes sGC to endogenous nitric oxide and directly stimulates sGC, leading to increased cGMP production. This results in vasodilation (widening of blood vessels), reduced pulmonary vascular resistance, and improved oxygen transport.
Dosage and Administration:
- Starting Dose: 1 mg three times daily.
- Titration: Dose is gradually increased to 2.5 mg three times daily, depending on individual tolerance and response.
- Maximum Dose: 2.5 mg three times daily.
- Administration:
- Take orally with or without food.
- Tablets should be swallowed whole with water.
- Consistent dosing times are recommended for optimal results.
Safety Information and Precautions:
- Contraindications:
- Pregnancy: Can cause serious birth defects. Women of childbearing age must use reliable contraception during treatment and undergo monthly pregnancy tests.
- Nitrates or Nitric Oxide Donors: Concurrent use can cause severe hypotension.
- PDE5 Inhibitors (e.g., Sildenafil, Tadalafil): Combined use is not recommended.
- Common Side Effects:
- Headache.
- Dizziness.
- Indigestion.
- Hypotension (low blood pressure).
- Nausea and vomiting.
- Serious Risks:
- Hypotension: Monitor blood pressure regularly.
- Bleeding: Increased risk of bleeding complications.
- Pulmonary Hemorrhage: Rare but potentially fatal in patients with pulmonary veno-occlusive disease (PVOD).
Special Warnings:
- Avoid Grapefruit Juice: It may increase Riociguat levels in the bloodstream.
- Avoid Smoking: Smoking reduces Riociguat concentration, reducing effectiveness.
- Kidney and Liver Disease: Dose adjustments may be necessary.
- Elderly Patients: Careful dose titration is required.
Why Choose Adempas (Riociguat) 2.5 mg?
- First-in-Class sGC Stimulator: The only approved medication in its class for CTEPH and PAH.
- Improves Exercise Capacity: Helps patients walk longer distances and breathe more easily.
- Delays Disease Progression: Reduces worsening of symptoms and hospitalizations.
- Trusted Manufacturer: Bayer Pharmaceuticals, a leader in cardiovascular and respiratory medicine.
- Well-Tolerated: Suitable for long-term use under medical supervision.
Storage Instructions:
- Store at room temperature below 25°C.
- Keep away from moisture and direct sunlight.
- Keep out of reach of children.
Who Can Benefit from Adempas?
- Patients diagnosed with CTEPH who are inoperable or have persistent symptoms after surgery.
- Individuals suffering from Pulmonary Arterial Hypertension (PAH), including idiopathic or heritable PAH, and PAH associated with connective tissue disease.
Manufacturer Information:
- Brand: Adempas 2.5 mg
- Active Substance: Riociguat
- Presentation: 42 Film-Coated Tablets.
- Manufacturer: Bayer Pharmaceuticals
- Country of Origin: Germany
Ordering Adempas 2.5 mg Online:
Secure your supply of Adempas (Riociguat) 2.5 mg from our trusted online pharmacy platform with global shipping options. Benefit from competitive pricing and authentic pharmaceutical products, ensuring fast delivery and customer satisfaction.
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