Actilyse 50 mg Vial Buy – Alteplase Lyophilized Powder for Solution for Infusion

Actilyse 50 mg Vial is a trusted and highly effective thrombolytic agent containing Alteplase, a recombinant tissue plasminogen activator (rt-PA), developed by Boehringer Ingelheim. This medication is primarily used for the rapid dissolution of blood clots in life-threatening cardiovascular emergencies, such as acute ischemic stroke, myocardial infarction (heart attack), and pulmonary embolism.

As a fibrinolytic enzyme, Actilyse (Alteplase) works by converting plasminogen to plasmin, the enzyme responsible for dissolving fibrin clots. It is a critical emergency medicine in stroke and cardiac care units globally.

Key Benefits and Features:

• Active Ingredient: Alteplase (recombinant) – 50 mg per vial.
• Formulation: Lyophilized powder for reconstitution with sterile water for injection.
• Administration: Intravenous (IV) infusion only, under strict medical supervision.
• Indications:
  • Acute Ischemic Stroke: Administered within 4.5 hours of symptom onset to restore cerebral blood flow and minimize brain damage.
  • Acute Myocardial Infarction (STEMI): Administered within 6-12 hours of chest pain onset to dissolve coronary thrombus and restore blood supply to the heart.
  • Pulmonary Embolism (PE): Used for massive pulmonary embolism with hemodynamic instability to prevent cardiopulmonary collapse.
• Rapid Onset: Begins dissolving clots within minutes, improving patient survival and recovery outcomes.
• WHO Essential Medicine: Recognized as an essential thrombolytic agent for emergency cardiovascular and stroke care.

How Actilyse (Alteplase) Works:

Actilyse (Alteplase) is a genetically engineered recombinant tissue plasminogen activator (rt-PA) that binds to fibrin in thrombi (blood clots). Upon activation, it converts plasminogen to plasmin, which breaks down fibrin clots, allowing restoration of normal blood flow to vital organs, particularly the brain, heart, and lungs.

Dosage and Administration:

• Acute Ischemic Stroke:
  • 0.9 mg/kg (maximum 90 mg) over 60 minutes.
  • 10% of the dose is given as a bolus over 1 minute, followed by the remainder as an infusion over 60 minutes.
• Acute Myocardial Infarction:
  • Accelerated Infusion Protocol (preferred):
    • 15 mg IV bolus, followed by 0.75 mg/kg (up to 50 mg) over 30 minutes, then 0.5 mg/kg (up to 35 mg) over the next 60 minutes.
• Pulmonary Embolism:
  • 100 mg IV infusion over 2 hours.

Reconstitution:
Reconstitute lyophilized powder with sterile water for injection (50 mL) provided with the vial.
Use a vented transfer device (included) for aseptic preparation.

Safety and Precautions:

• Strict Medical Supervision Required: Due to high risk of bleeding.
• Contraindications:
  • Active internal bleeding.
  • Severe uncontrolled hypertension.
  • Recent surgery or trauma (within 3 months).
  • History of hemorrhagic stroke or intracranial hemorrhage.
• Common Side Effects:
  • Bleeding (including intracranial hemorrhage).
  • Hypotension.
  • Nausea.
• Serious Risks:
  • Intracranial Hemorrhage: Most critical complication.
  • Allergic Reactions: Rare but possible.
  • Arrhythmias (reperfusion arrhythmia) during myocardial infarction treatment.

Special Handling Instructions:

• Yüksek Riskli İlaç – High-Risk Medication: Strict monitoring during and after administration.
• Storage:
  • Store below 25°C.
  • Reconstituted solution is stable for 8 hours at 2-8°C, but immediate use is recommended.

Why Choose Actilyse 50 mg Alteplase?

• Gold Standard Thrombolytic: Recognized globally for stroke and heart attack treatment.
• Proven Life-Saving Therapy: Reduces mortality and disability when administered promptly.
• Trusted Manufacturer: Boehringer Ingelheim, a world-renowned pharmaceutical leader.
• Fast-Acting and Efficient: Rapid clot dissolution for immediate vascular restoration.
• Recommended by Guidelines: Endorsed by American Stroke Association and European Society of Cardiology.

Manufacturer Information:

• Brand: Actilyse 50 mg
• Active Substance: Alteplase (Recombinant Tissue Plasminogen Activator – rt-PA)
• Presentation: 1 Vial (Lyophilized Powder) + Solvent (Sterile Water) + Transfer Cannula
• Manufacturer: Boehringer Ingelheim
• Country of Origin: Germany

Suitable For:

• Emergency Departments, Stroke Units, Intensive Care Units (ICU).
• Cardiologists, Neurologists, Emergency Physicians.
• Hospitals with Thrombolysis and Stroke Management Facilities.

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